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Updated: Mar 13, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles
Dong-Chao Wang1,2, Ming-Sheng Xie2, Hai-Ming Guo3,4
1School of Environment, Henan Normal University, Xinxiang, 453007, China.
Abstract:
A highly enantioselective dearomative [3+2] cycloaddition of benzothiazole has been successfully developed. A wide range of benzothiazoles and cyclopropane-1,1-dicarboxylates are suitable substrates for this reaction. The desired hydropyrrolo[2,1-b]thiazole compounds were obtained in excellent enantioselectivity and yields (up to 97 % ee and 97 % yield). With the same catalytic system, a highly efficient kinetic resolution of 2-substituted cyclopropane-1,1-dicarboxylates was also realized.
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