Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

978
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
978
Increased Body Temperature01:25

Increased Body Temperature

7.6K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

581
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
581
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.0K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.0K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

999
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
999
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

742
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
742

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence-Based Medicine Meets Artificial Intelligence: Reframing Critical Appraisal in Emergency Medicine.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicineยท2026
Same author

Improving opioid substitution therapy in the acute hospital setting: implementation of a best practice guideline.

BMJ open qualityยท2026
Same author

Dengue and chikungunya vaccination in military populations, a comment on Bogacka et al.

Travel medicine and infectious diseaseยท2026
Same author

Incidence, risk factors and management of paradoxical reaction in central nervous system tuberculosis in the United Kingdom.

The Journal of infectionยท2026
Same author

Subduction modulated the long-term oxygenation of Earth's surface.

Proceedings of the National Academy of Sciences of the United States of Americaยท2026
Same author

Translational development of an SGLT2-targeted near-infrared contrast agent for intraoperative imaging of early-stage lung cancer.

EJNMMI researchยท2026

Related Experiment Video

Updated: Mar 13, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

1.2K

Pyrexia of unknown origin in clinical practice.

Tehmina Bharucha1, Beatrice Cockbain2, Michael Brown3

  • 1Specialist Trainee and Academic Clinical Fellow in the Department of Infectious Diseases and Microbiology, Royal Free Hospital, London NW3 2QG.

British Journal of Hospital Medicine (London, England : 2005)
|October 11, 2016
PubMed
Summary

This article reviews pyrexia of unknown origin (FUO) to align with modern clinical practice. It details the term's evolution and presents essential questions for evaluating FUO cases.

More Related Videos

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
03:42

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

Published on: March 15, 2024

1.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

1.2K
Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
03:42

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

Published on: March 15, 2024

1.3K

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Pyrexia of unknown origin (FUO) is a diagnostic challenge.
  • The definition and investigation of FUO have evolved significantly over time.
  • Current clinical practice requires updated approaches to FUO evaluation.

Purpose of the Study:

  • To revisit and update the concepts of pyrexia of unknown origin.
  • To reflect the current clinical practice and diagnostic landscape for FUO.
  • To provide a framework for evaluating FUO cases.

Main Methods:

  • Literature review and synthesis of current clinical guidelines.
  • Analysis of the historical evolution of FUO diagnostic criteria.
  • Development of key questions for FUO patient assessment.

Main Results:

  • The term FUO has evolved in response to advancements in diagnostic technology and understanding of disease patterns.
  • A structured approach, guided by key questions, is crucial for efficient FUO diagnosis.
  • Modern investigations emphasize a broader differential diagnosis and targeted testing.

Conclusions:

  • Current clinical practice necessitates a dynamic and updated approach to pyrexia of unknown origin.
  • Effective evaluation of FUO relies on a thorough history, physical examination, and judicious use of diagnostic tools.
  • Key questions can guide clinicians in navigating the complexities of FUO and reaching a timely diagnosis.