Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functional Brain Systems: Reticular Formation

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distributed cortical network dynamics of binocular convergent eye movements in humans.

Network neuroscience (Cambridge, Mass.)·2026

Same author

Cognitive reappraisal of food and emotion cues involves common and unique neural contributions.

bioRxiv : the preprint server for biology·2026

Same author

Investigating the analytical robustness of the social and behavioural sciences.

Nature·2026

Same author

Symbolic fractions have greater neural representational similarity with discretized than continuous nonsymbolic proportional reasoning.

Neuropsychologia·2026

Same author

Dynamically shifting from compositional to conjunctive brain representations supports cognitive task learning.

Nature communications·2025

Same author

Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding.

Imaging neuroscience (Cambridge, Mass.)·2025

Search research articles

Related Experiment Video

Updated: Mar 13, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Activity flow over resting-state networks shapes cognitive task activations.

Michael W Cole¹, Takuya Ito¹, Danielle S Bassett^2,3

¹Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.

Nature Neuroscience

|November 8, 2016

Summary

Resting-state functional connectivity (FC) predicts cognitive task activations by modeling how brain activity spreads across intrinsic networks. This reveals a key mechanism linking brain organization at rest to task-related brain function.

More Related Videos

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

Related Experiment Videos

Last Updated: Mar 13, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

Area of Science:

Neuroscience
Cognitive Neuroscience
Computational Neuroscience

Background:

Resting-state functional connectivity (FC) reveals intrinsic brain network organization.
The relationship between resting-state FC and cognitive task activations remains unclear.
Task-evoked activity flow is a potential mechanism linking these two phenomena.

Purpose of the Study:

To investigate how task-evoked activity flow over intrinsic networks relates to cognitive task activations.
To determine if activity flow over resting-state FC networks can predict cognitive task activations.

Main Methods:

Developed a large-scale neural network model to estimate task-evoked activity flow over resting-state FC networks.
Applied the model to empirical functional MRI data.
Predicted cognitive task activations in held-out brain regions and individuals.

Main Results:

Task-evoked activity flow over resting-state FC networks successfully predicted cognitive task activations.
Predictions were accurate in both novel brain regions and across different individuals.
This demonstrates the predictive power of activity flow dynamics on intrinsic networks.

Conclusions:

Task-evoked activity flow over intrinsic functional connectivity networks is a significant large-scale mechanism.
This mechanism explains the strong relationship between resting-state brain organization and cognitive task performance.
Findings provide a novel framework for understanding brain function during cognitive tasks.