Related Experiment Video

Updated: Oct 9, 2026

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

22.1K

Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

Eun-Sil Park1, Michio Suzuki1, Masanobu Kimura1

  • 1Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.

BMC Veterinary Research
|October 12, 2016
PubMed
Abstract

Insights

Feline morbillivirus (FmoPV) infects domestic cats in Japan, with nearly half showing persistent infection. FmoPV infection is linked to feline renal disease inflammation, but not specifically tubulointerstitial nephritis (TIN).

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases
  • Renal Pathology

Background:

  • Feline morbillivirus (FmoPV) is a novel paramyxovirus identified in domestic cats globally.
  • FmoPV is suspected to contribute to feline renal diseases, such as tubulointerstitial nephritis (TIN).

Purpose of the Study:

  • To determine the prevalence and characteristics of FmoPV infection in domestic cats in Japan.
  • To investigate the association between FmoPV infection and feline renal diseases.

Main Methods:

  • An epidemiological survey involving indirect immunofluorescence assay (IF) for antibodies and RT-PCR for viral RNA in serum, urine, and renal tissues.
  • Immunohistochemistry (IHC) was used to detect FmoPV-N protein in kidney tissues.

Main Results:

  • Prevalence of FmoPV infection (RNA and/or antibodies) was 29% in 100 domestic cats.
  • Approximately 50% of infected cats (15/29) exhibited persistent FmoPV infection (RNA+/Ab+).
  • FmoPV-N protein was detected in kidney tissues of 19/29 infected cats, with severe inflammation in only 4/19.

Conclusions:

  • A significant association exists between FmoPV infection and inflammatory changes in feline renal lesions.
  • Histopathological evidence directly linking FmoPV infection to tubulointerstitial nephritis (TIN) was not established in this study.
Keywords:
CatEpidemiologyFeline morbillivirusInflammationKidney disease

More Related Videos

Standard Operating Procedure for Lyssavirus Surveillance of the Bat Population in Taiwan07:55

Standard Operating Procedure for Lyssavirus Surveillance of the Bat Population in Taiwan

Published on: August 27, 2019

8.0K
Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses08:10

Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses

Published on: May 2, 2019

8.9K

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...