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Early hematopoiesis in multiple sclerosis patients

Daniel Jons1, Maria Kneider1, Linda Fogelstrand2

  • 1Section of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.

Journal of Neuroimmunology
|October 12, 2016
PubMed

Insights

In multiple sclerosis (MS) patients, early B cell development in bone marrow appears normal. However, a reduced proportion of natural killer T cells was observed in the bone marrow of MS patients.

Area of Science:

  • Immunology
  • Neurology
  • Hematology

Background:

  • Multiple sclerosis (MS) immunopathology is thought to originate in the peripheral lymphatic system.
  • The precise location and nature of the initiating events in MS remain unclear.

Purpose of the Study:

  • To investigate early hematopoiesis in the bone marrow of MS patients.
  • To compare the proportions of specific immune cell subsets in the bone marrow of MS patients and healthy controls.

Main Methods:

  • Flow cytometry (FACS) analysis was used to examine bone marrow cell subsets.
  • The study included 9 MS patients and 11 neurologically healthy controls.

Main Results:

  • A statistically significant lower proportion of natural killer T cells (P=0.045) was found in the bone marrow of MS patients compared to controls.
  • Proportions of hematogenous stem cells, myeloblasts, and B cell precursor subsets did not differ between the two groups.

Conclusions:

  • This pilot study suggests that early B cell lineage development in the bone marrow is not significantly altered in MS patients.
  • Further research is needed to elucidate the role of natural killer T cells in MS pathogenesis.
Keywords:
B cellBone marrowFACSMultiple sclerosisNKT cellPrecursor

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