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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Gut microbiota and central nervous system development
Nicola Principi1, Susanna Esposito1
1Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
The Journal of Infection
|October 12, 2016
Summary
Gut dysbiosis, or an imbalance in gut bacteria, is linked to central nervous system (CNS) issues. More research is needed to understand the gut-brain axis and its role in neurological conditions.
Area of Science:
- Neuroscience
- Microbiology
- Developmental Biology
Background:
- Gut dysbiosis is increasingly linked to central nervous system (CNS) development and function.
- Understanding the gut-brain axis is crucial for addressing neurological conditions.
Purpose of the Study:
- To review the relationship between gut microbiota and CNS development.
- To explore the implications of gut dysbiosis for neurological health.
Main Methods:
- A comprehensive literature search was conducted using PubMed.
- Keywords included "microbiota," "gut," "intestinal," and "nervous system."
- Studies published in English over the last 15 years focusing on neurologic diseases were evaluated.
Main Results:
- Gut microbiota significantly influences CNS development and function.
- Gut dysbiosis is associated with notable neurological problems.
- Most current data originates from animal models, limiting direct human applicability.
Conclusions:
- Probiotics and prebiotics may impact the CNS, but effects vary by specific microbial species or oligosaccharides.
- Human gut microbiota is influenced by multiple, often simultaneous, factors, especially in children.
- Further research is essential to elucidate the complex behaviors influenced by the gut microbiota and the underlying mechanisms involved in the gut-brain axis.
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