[Excretion of phenoltetrachlorophthalein in the bile in rats]

Phenoltetrachlorphthalein secretion into bile was followed in Wistar strain rats intoxicated per os by tetrachlormethane (0.25, 0.50, 2.00, and 3.00 ml/kg) after 1, 2, 4 and 8 days after intoxication. Biotransformation processes resulting in the formation of phenoltetrachlorphthalein metabolites are altered during the intoxication unequally. So far mutual relation of secreted metabolites has not been proved to serve generally as a simple criterion for absolute activity assessment of hepatic glucuroniltransferase or other hepatic enzymes.