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Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment
Takahiro Takazono1, Toyomitsu Sawai, Masato Tashiro
1Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Abstract:
A 35-year-old non-HIV patient developed pulmonary cryptococcosis after the initiation of infliximab. He recovered by fluconazole treatment and completed the therapy for a total of 6 months. However, he experienced a relapse 16 months later during retreatment with infliximab, revealing an interesting clinical course contradicting retreatment. This case also represents the first case of relapsed pulmonary cryptococcosis suspected during treatment with a biologic agent. Both of these aspects generated important clinical questions about the length of pulmonary cryptococcosis treatment and the necessity of introducing a second prophylaxis for such patients.
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