Related Experiment Video
Updated: Mar 13, 2026
11:51
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
Published on: March 1, 2016
11.0K
Comment on: "Cell therapy for heart disease: Trial sequential analyses of two cochrane reviews"
G Castellini1,2,3, E E Nielsen3, C Gluud3
1Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Clinical Pharmacology and Therapeutics
|October 12, 2016
Abstract:
Trial Sequential Analysis (TSA) is a frequentist method to help researchers control the risks of random errors in meta-analyses.1 Fisher et al.2 used TSA on cell therapy for heart diseases. The present article discusses the usefulness of TSA and its dependence on the choice of the parameters for calculation of the required information size and the adjacent monitoring boundaries, and comments on the approach by Fisher et al.2.
