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Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism
Ahmet Goktug Ertem1, Cagri Yayla1, Burak Acar1
1Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Introduction:
The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc).
Objectives:
We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE.
Methods:
The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors.
Results:
LMR was significantly lower in non-survivors after APE (P < .001). Neutrophil-to-lymphocyte ratio (NLR) was higher in non-survivors after APE (P < .001). Platelet-to-lymphocyte (PLR) had no significance between both groups (P: .241). Simplified pulmonary embolism severity index and LMR were independent predictors of mortality in patients with APE (P: .008 and P: .001, respectively).
Conclusion:
LMR as a novel marker of inflammation seemed to be an independent predictor of short-term mortality in patients with APE.
Insights
The lymphocyte-to-monocyte ratio (LMR) is a significant predictor of short-term mortality in acute pulmonary embolism (APE) patients. Lower LMR indicates higher mortality risk, highlighting its potential as a novel inflammatory marker.
Area of Science:
- Cardiology
- Pulmonology
- Inflammation Research
Background:
- Inflammation markers are studied for predicting mortality in acute pulmonary embolism (APE).
- Previous research explored ratios like platelet-to-lymphocyte ratio (PLR).
Purpose of the Study:
- To evaluate the predictive value of lymphocyte-to-monocyte ratio (LMR) for 30-day mortality in APE patients.
- To identify novel inflammatory markers for risk stratification in APE.
Main Methods:
- Analysis of 264 APE patients, including 230 survivors and 34 non-survivors.
- Comparison of LMR, neutrophil-to-lymphocyte ratio (NLR), and PLR between survivor and non-survivor groups.
Main Results:
- LMR was significantly lower in non-survivors (P < .001).
- NLR was significantly higher in non-survivors (P < .001).
- LMR and simplified pulmonary embolism severity index were independent predictors of mortality (P = .001 and P = .008, respectively).
Conclusions:
- LMR is a novel, independent predictor of short-term mortality in APE patients.
- LMR serves as a valuable inflammatory marker for risk assessment in APE.
