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[Antibiotic prevention with aztreonam in urologic surgery in children]
Insights
Aztreonam antibiotic prophylaxis effectively prevented surgical infections in 96% of pediatric patients undergoing surgery, with minimal side effects. This study highlights its safety and efficacy in preventing Gram-negative bacterial infections in children requiring urinary catheters.
Area of Science:
- Pediatric Surgery
- Infectious Disease Prevention
- Pharmacology
Abstract:
In a group of 51 children aged 3 days-17 years old, 40 were given operative 8 endoscopic and 3 percutaneous surgery, while all received antibiotic prophylaxis with Aztreonam (Squibb Azactam) for the prevention of surgical infections. Preoperative uroculture revealed sterile urine in all 51 but 49 needed excretory catheters at various levels: urethral, pyelic. Drug treatment was started preoperatively at the time of narcosis and continued until catheter removal. Aztreonam was chosen for its anti-Gram negative action and absence of toxicity as reported in the literature. Urine cultures at the end of treatment and 7 days later revealed sterile urine in 49 (96%) of the children, while 2 presented asymptomatic infection by Gram positive bacteria. No significant side effects definitely attributable to the drug were encountered.