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Exercise, fasting, and mimetics: toward beneficial combinations?

Richard T Jaspers¹, M Carola Zillikens², Edith C H Friesema³

¹Laboratory for Myology, Move Research Institute Amsterdam, Faculty of Behavioral and Movement Sciences, Vrije Universiteit (VU) Amsterdam, Amsterdam, The Netherlands.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|October 13, 2016

Summary

Combining fasting and exercise offers unique benefits for metabolic health, promoting muscle repair over autophagy. These combined strategies show promise in treating metabolic disorders like obesity and type 2 diabetes.

Keywords:

metabolic syndrome signal transduction skeletal muscle

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Area of Science:

Metabolic signaling pathways
Exercise physiology
Nutritional biochemistry

Background:

Obesity and type 2 diabetes are linked metabolic disorders affecting multiple tissues.
Skeletal muscle is crucial for blood glucose regulation, with overlapping metabolic effects from fasting and exercise.
Fat metabolism changes in adipose tissue and liver are observed during fasting and exercise.

Approach:

This review synthesizes current research on the molecular mechanisms of fasting, exercise, and their mimetics.
It examines individual and combined effects in skeletal muscle and other organs in rodents and humans.
The focus is on signal transduction pathways influenced by these interventions.

Key Points:

Combined fasting/exercise promotes muscle repair pathways, distinct from individual interventions.
Exercise mimetics are explored alongside fasting and exercise for metabolic benefits.
Interactions between fasting, exercise, and mimetics impact various tissues, including muscle, liver, and adipose tissue.

Conclusions:

Understanding the combined effects of fasting, exercise, and mimetics is key to developing novel therapeutic strategies.
Targeting these combined mechanisms holds potential for improving metabolic disorders.
Further research is needed to optimize these combinations for clinical application.