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Updated: Mar 13, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
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Published on: December 31, 2014

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The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis

Nour Ghazzaui1, Alexis Saintamand1, Hussein Issaoui1

  • 1Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.

Oncotarget
|October 13, 2016
PubMed

Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis-regulatory enhancers. Those located in the IgH 3' regulatory region (3'RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3'RR's contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3'RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis.

Keywords:
3’ regulatory regionHDACc-myclymphomagenesistransgenic mice

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