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Updated: Mar 13, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection
Jong Man Kim1, Kwang-Woong Lee2, Gi-Won Song3
1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea.
Background/Aims:
The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR.
Methods:
We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers.
Results:
BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive.
Conclusion:
The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival.
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