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Related Concept Videos

Angina II: Classification01:27

Angina II: Classification

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Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
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Angina IV: Management01:26

Angina IV: Management

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IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
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Glucagon-like Receptor Agonists01:24

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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Angina I: Introduction01:30

Angina I: Introduction

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Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

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Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
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Updated: Mar 13, 2026

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor
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Cangrelor.

Danial E Baker1, Kyle T Ingram2

  • 1Director, Drug Information Center , and Professor of Pharmacy Practice, College of Pharmacy, Washington State University Spokane.

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Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs for Pharmacy & Therapeutics Committees, including drug utilization evaluations and drug class reviews. Subscribers receive print and online access to detailed information on new and investigational drugs.

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Area of Science:

  • Pharmacology
  • Drug Development
  • Clinical Pharmacy

Background:

  • The Formulary Monograph Service offers detailed monographs on newly released and late-stage investigational drugs.
  • Content is specifically designed for Pharmacy & Therapeutics Committees, aiding formulary decisions.
  • Monthly publications include drug utilization evaluations (DUE/MUE) and drug class reviews.

Discussion:

  • Monographs provide comprehensive documentation for drugs entering clinical practice.
  • The service supports evidence-based medication use through detailed evaluations.
  • Customizable options ensure relevance to individual healthcare facility needs.

Key Insights:

  • Provides timely information on emerging pharmacotherapies.
  • Facilitates informed decision-making for drug selection and utilization.
  • Enhances pharmacy and nursing in-service education.

Outlook:

  • Continued delivery of critical drug information to healthcare professionals.
  • Potential for expanded drug class reviews and safety evaluations.
  • Integration of print and online access for user convenience.