Related Experiment Video

Updated: Mar 13, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.2K

Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer's disease

Wei Li1, Tao Wang1, Shifu Xiao1

  • 1Alzheimer's Disease and Related Disorders Center; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Neuropsychiatric Disease and Treatment
|October 13, 2016
PubMed
Abstract

Insights

Type 2 diabetes mellitus (T2DM) is a significant risk factor for Alzheimer's disease (AD) progression in older adults. This study found T2DM strongly associated with increased odds of developing AD from mild cognitive impairment (MCI).

Area of Science:

  • Neuroscience
  • Gerontology
  • Endocrinology

Background:

  • Mild cognitive impairment (MCI) is a precursor to Alzheimer's disease (AD).
  • Type 2 diabetes mellitus (T2DM) is linked to cognitive changes, but its role in MCI progression to AD is unclear.

Purpose of the Study:

  • To investigate the relationship between T2DM and MCI in elderly Shanghai residents.
  • To determine if T2DM exacerbates cognitive decline in the elderly.

Main Methods:

  • 197 elderly participants were assessed for T2DM, hyperlipidemia, brain injury, and dementia history.
  • Cognitive function evaluated using Mini-Mental State Examination and Montreal Cognitive Assessment.
  • Diagnoses based on DSM-IV for AD and Petersen's criteria for MCI.

Main Results:

  • 41.6% had no cognitive impairment, 41.6% had MCI, and 16.8% had AD.
  • Multivariate logistic regression showed T2DM as a significant risk factor for AD (OR=49.723).

Conclusions:

  • T2DM may increase the risk of mild cognitive impairment progressing to Alzheimer's disease.
  • Findings highlight T2DM as a critical factor in AD pathogenesis.
Keywords:
ADMCIT2DMrisk factor

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.2K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

34.1K

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
594
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.9K
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
656
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.8K