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Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation:

Anna E Kersh1, Maiko Sasaki2, Lee A Cooper3

  • 1Medical Scientist Training Program, Emory University School of Medicine Atlanta, GA, USA.

Frontiers in Pharmacology
|October 13, 2016
PubMed

Insights

Molecular pathology advances cancer treatment. Understanding how oncogenic events like ErbB/HER activation influence anti-tumor immunity and neoantigen presentation is key for personalized medicine.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Immunology

Background:

  • Molecular pathology provides detailed cancer insights, guiding targeted therapies but leaving immune-based treatments less defined.
  • The role of neoantigens in predicting response to immune checkpoint blockade is known, yet their impact on targeted therapies remains unclear.
  • Personalized medicine requires integrating oncogenic events with anti-tumor immunity processes.

Approach:

  • Investigating the relationship between oncogenic events and anti-tumor immunity.
  • Focusing on how ErbB/HER activation and signal transduction pathways affect antigen processing and presentation.

Key Points:

  • Molecular alterations in cancer inform targeted therapy but not immune therapy.
  • Neoantigen expression's impact on targeted therapy response is unknown.
  • ErbB/HER pathway activation influences antigen processing and presentation.

Conclusions:

  • Further research is needed to integrate molecular alterations with anti-tumor immunity for effective personalized cancer care.
  • Understanding ErbB/HER signaling's role in antigen presentation is crucial for developing novel immunotherapies.
Keywords:
EGFRErbB receptorsMHC class IMHC class IIgene expression regulationimmunologysignal transduction

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