Related Experiment Video
Updated: Mar 13, 2026
10:25
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
49.6K
Comparative Study of Voxel-Based Epileptic Foci Localization Accuracy between Statistical Parametric Mapping and
Kailiang Wang1, Tinghong Liu1, Xiaobin Zhao2
1Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neurostimulation, Beijing, China.
Frontiers in Neurology
|October 13, 2016
Summary
Statistical Parametric Mapping (SPM) and 3D Stereotactic Surface Projection (3D-SSP) improve epileptic focus detection in Fluorine-18-fluorodeoxyglucose Positron-Emission Tomography (18F-FDG-PET) scans. Both methods show similar consistency with the presumed epileptogenic zone.
Area of Science:
- Neurology
- Nuclear Medicine
- Medical Imaging Analysis
Background:
- Fluorine-18-fluorodeoxyglucose Positron-Emission Tomography (18F-FDG-PET) is crucial for localizing the epileptogenic focus in drug-refractory epilepsy patients undergoing presurgical evaluation.
- Voxel-based brain mapping techniques, Statistical Parametric Mapping (SPM) and 3D Stereotactic Surface Projection (3D-SSP), enhance the detection rates of seizure foci from 18F-FDG-PET scans.
- Comparing the consistency of epileptic focus detection between SPM and 3D-SSP is essential for optimizing presurgical evaluation strategies.
Purpose of the Study:
- To compare the consistency of epileptic focus detection between SPM and 3D-SSP using 18F-FDG-PET brain mapping analysis.
- To evaluate the performance of these methods against visual assessment, MRI lesion location, and presumed epileptogenic zone (PEZ).
- To assess the concordance of PET analyses with histopathology and surgical outcomes in patients who underwent lesion resection.
Main Methods:
- Retrospective review of clinical, electroencephalographic, and brain imaging data from 35 patients with refractory epilepsy.
- Re-evaluation of 18F-FDG-PET studies using SPM, 3D-SSP, and visual assessment, compared against MRI and PEZ.
- A secondary consistency study compared PET findings with histopathology and surgical outcomes in 19 patients.
Main Results:
- SPM (29/35) and 3D-SSP (25/35) showed significantly higher consistency with the PEZ compared to MRI (10/35) and visual assessment (14/35).
- No significant differences in PEZ concordance were found between SPM and 3D-SSP, or between visual assessment and MRI.
- In surgical cases, concordance with histopathology/outcomes was comparable across SPM (14/19), 3D-SSP (15/19), visual assessment (14/19), and MRI (9/19).
Conclusions:
- Voxel-based 18F-FDG-PET brain mapping with SPM or 3D-SSP improves epileptic focus detection over visual assessment and MRI.
- SPM and 3D-SSP demonstrate similar consistency with the PEZ.
- 3D-SSP is recommended for initial evaluation due to software efficiency, while SPM is suited for complex lesions; combined application offers optimal localization.
