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Status of stem cells in diabetic nephropathy: predictive and preventive potentials
Babak Baban1, Jun Yao Liu2, Samuel Payne3
1Department of Oral Biology; CL-2140, Dental College of Georgia, Augusta University, Augusta, GA 30912-1128 USA ; Department of Surgery, Section of Plastic Surgery, Medical College of Georgia, Augusta, GA 30912 USA.
The EPMA Journal
|October 13, 2016
Summary
Diabetes increases stem cell apoptosis, leading to reduced stem cell numbers in blood and kidneys. This decline in stem cells contributes to diabetic kidney disease progression.
Area of Science:
- Stem cell biology
- Diabetology
- Nephrology
Background:
- Stem cell recruitment aids tissue repair.
- The impact of diabetes on stem cell viability is unclear.
- Diabetes may lead to stem cell reduction and kidney disease.
Purpose of the Study:
- To test if diabetes mellitus increases stem cell apoptosis.
- To determine if reduced stem cells contribute to type 2 diabetic nephropathy.
Main Methods:
- Assessed endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and hematopoietic stem cells (HSCs) in db/db mice and controls.
- Examined stem cell status in peripheral blood and renal tissue.
- Investigated apoptosis in diabetic stem cell subsets.
Main Results:
- Reduced EPCs in peripheral blood of db/db mice.
- Decreased EPCs, MSCs, and HSCs in kidney tissue of db/db mice.
- Increased apoptosis of stem cell subsets in kidneys of db/db mice.
Conclusions:
- Diabetes causes stem cell subset decline in blood and kidneys, linked to apoptosis.
- Stem cell apoptosis contributes to renal failure in diabetes.
- Monitoring blood stem cell levels may predict diabetic complications.
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