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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Fertilization01:38

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
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Add-ons in IVF programme - Hype or Hope?

A K Datta1, S Campbell1, B Deval1

  • 1CREATE Fertility, 150 Cheapside, St Pauls, London EC2V 6ET, United Kingdom.

Facts, Views & Vision in Obgyn
|October 13, 2016
PubMed
Summary
This summary is machine-generated.

This review examines new technologies and adjuvant therapies for improving in vitro fertilization (IVF) success rates. It assesses current evidence for commonly used interventions, guiding clinical application pending further research.

Keywords:
AdjuvantsIVFassisted conceptionassisted reproductionmalpracticeover-treatmenttechnology

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Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • In vitro fertilization (IVF) success rates can be improved with novel technologies and adjuvant therapies.
  • Commonly prescribed pharmacological adjuvants include dehydroepiandrosterone, growth hormones, Coenzyme Q10, and immune therapies.
  • Emerging technologies for IVF enhancement encompass advanced sperm selection, time-lapse embryo monitoring, and preimplantation genetic screening.

Approach:

  • This review critically evaluates the existing scientific evidence supporting the use of various co-interventions in IVF.
  • The study aims to determine the current justification for employing these adjuncts in clinical practice.
  • It also considers which interventions might be cautiously used while awaiting more definitive research findings.

Key Points:

  • Pharmacological adjuvants such as dehydroepiandrosterone, growth hormones, and Coenzyme Q10 are frequently used in IVF.
  • Advanced techniques like time-lapse embryo monitoring and preimplantation genetic screening are being explored to optimize IVF outcomes.
  • Evidence for the efficacy of many adjunct therapies and technologies requires further robust validation.

Conclusions:

  • The clinical utility of numerous adjuvant therapies and novel technologies in IVF remains under investigation.
  • A critical appraisal of current evidence is necessary to guide the judicious application of these interventions.
  • Further research is essential to confirm or refute the role of these co-interventions in improving IVF success.