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Updated: Mar 13, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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Cell Proliferation and Apoptosis in ADPKD

Eun Ji Lee1

  • 1Molecular Medicine Laboratory, Department of Life systems, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, South Korea. eunji8902@sm.ac.kr.

Advances in Experimental Medicine and Biology
|October 13, 2016
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) involves increased kidney cell proliferation and altered apoptosis. These processes disrupt normal kidney function, leading to cyst formation and disease progression.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is characterized by increased renal tubular epithelial cell proliferation and fluid secretion.
  • Mutations in PKD1 or PKD2 disrupt intracellular calcium homeostasis and cyclic adenosine monophosphate (cAMP) accumulation.
  • These disruptions lead to altered signaling pathways regulating cell proliferation and contribute to cyst development.

Purpose of the Study:

  • To discuss the mechanisms of cell proliferation and apoptosis in ADPKD progression.
  • To explore the interplay between signaling pathways regulating these cellular processes in ADPKD.

Main Methods:

  • Review of existing literature on ADPKD pathogenesis.
  • Analysis of signaling pathways involved in cell proliferation and apoptosis.

Main Results:

  • Increased tubular epithelial cell proliferation and dysregulated apoptosis are key features of ADPKD.
  • Disrupted calcium and cAMP homeostasis due to PKD1/PKK2 mutations drive aberrant cell signaling.
  • An imbalance between proliferation and apoptosis contributes to cyst growth and renal tissue remodeling.

Conclusions:

  • Cell proliferation and apoptosis play critical roles in ADPKD pathogenesis.
  • Understanding the crosstalk between signaling pathways is crucial for developing therapeutic strategies for ADPKD.
Keywords:
ADPKDApoptosisAutosomal dominant polycystic kidney diseaseProliferation

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