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Published on: September 1, 2015
Inflammation and Fibrosis in ADPKD
1Molecular Medicine Laboratory, Department of Life systems, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, South Korea.
Abstract:
Diverse signaling pathways have been reported to be associated with polycystic kidney disease (PKD). Cell proliferation is widely known to be an important pathway related to this disease. However, studies on the interactions of inflammation and fibrosis with polycystic kidney disease have been limited. Inflammation is one of the protective systems involved in the response to foreign molecules. In PKD, it was reported that the activity of signaling pathways associated with inflammation is increased. Also, fibrosis is the development of excess fibrous tissue in organ or tissue. It is an abnormal phenomenon in which the extent of fibrous connective tissues is increased. In PKD, increases in the activity of molecules such as growth factor and TGF-β have been reported to occur and promote fibrosis. Therefore, the inflammation and fibrosis responses have been suggested as therapeutic targets for PKD. In order to guide further studies, this review indicates the roles of inflammatory and fibrosis signaling in PKD.
Insights
Polycystic kidney disease (PKD) involves cell proliferation, but inflammation and fibrosis signaling are key, understudied pathways. Targeting these inflammatory and fibrotic responses may offer new therapeutic strategies for PKD.
Area of Science:
- Nephrology
- Molecular Biology
- Pathology
Background:
- Polycystic kidney disease (PKD) is linked to various signaling pathways, notably cell proliferation.
- The roles of inflammation and fibrosis in PKD pathogenesis are less understood.
- Inflammation and fibrosis are implicated in disease progression and represent potential therapeutic targets.
Purpose of the Study:
- To review the roles of inflammatory and fibrosis signaling pathways in polycystic kidney disease.
- To highlight the significance of inflammation and fibrosis as therapeutic targets for PKD.
Main Methods:
- Literature review of studies on signaling pathways in polycystic kidney disease.
- Analysis of the involvement of inflammation and fibrosis in PKD progression.
- Identification of key molecules and pathways related to inflammation and fibrosis in PKD.
Main Results:
- Increased activity of inflammation-associated signaling pathways is observed in PKD.
- Growth factors and TGF-β activity are elevated in PKD, promoting fibrosis.
- Inflammation and fibrosis are critical components of PKD pathology.
Conclusions:
- Inflammation and fibrosis are significant contributors to polycystic kidney disease.
- Targeting inflammation and fibrosis pathways presents a promising therapeutic avenue for PKD.
- Further research into these signaling pathways is crucial for developing effective PKD treatments.
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