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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Updated: Mar 13, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Epigenetic Regulation in Cystogenesis.

Yu Mi Woo1

  • 1Molecular Medicine Laboratory, Department of Life systems, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, South Korea. milkmi@sookmyung.ac.kr.

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Epigenetic modifications, like DNA methylation, are linked to kidney diseases. Targeting these epigenetic factors offers a promising, low-side-effect therapy for controlling cyst development in renal cystic diseases.

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CystEpigenetic regulationPKD

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Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • Epigenetic regulation involves heritable gene expression changes without altering DNA sequence.
  • Key epigenetic mechanisms include DNA methylation, histone modification, and microRNA regulation.
  • These mechanisms are implicated in various diseases, including cancers and precancerous conditions.

Purpose of the Study:

  • To review recent findings on epigenetic modifications in renal cystic diseases.
  • To explore the potential of targeting epigenetic regulation as a therapeutic strategy for cystogenesis.

Main Methods:

  • Literature review of recent studies on epigenetics and renal cystic diseases.
  • Analysis of the role of epigenetic alterations in cystogenesis.
  • Evaluation of therapeutic potential of targeting epigenetic factors.

Main Results:

  • Epigenetic changes are increasingly associated with renal cystic diseases, such as autosomal dominant polycystic kidney disease.
  • Restoration of altered epigenetic factors is emerging as a potential therapeutic target.
  • Targeting epigenetics may offer a novel approach with potentially minimal side effects.

Conclusions:

  • Epigenetic dysregulation plays a role in the pathogenesis of renal cystic diseases.
  • Targeting epigenetic mechanisms presents a promising therapeutic avenue for managing cystogenesis.
  • Further research into epigenetic therapies could revolutionize treatment for renal cystic diseases.