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Published on: January 6, 2011
Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction
Sarah K B Bick1,2, Bradley S Folley1,3, Jutta S Mayer4,5
1Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Objectives:
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task.
Materials And Methods:
We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task. Seven DBS patients were tested sequentially in the stimulation-on and stimulation-off states while on dopaminergic medication. Patients watched a series of positive, negative, and neutral videos. The general linear model was used to compare prefrontal oxygenated hemoglobin concentration between DBS states.
Results:
Deep brain stimulation was correlated with prefrontal oxygenated hemoglobin changes relative to the stimulation off state in response to both positive and negative videos. These changes were specific to emotional stimuli and were not seen during neutral stimuli.
Conclusions:
These results suggest that STN stimulation influences the prefrontal cortical representation of positive and negative emotion induction.
