Recent advances in X-ray compatible microfluidics for applications in soft materials and life sciences

Area of Science:

• Materials Science
• Analytical Chemistry
• Biophysics

Background:

• Advanced X-ray sources offer enhanced resolution and speed, necessitating improved sample preparation methods.
• Traditional sample preparation methods present limitations in handling small volumes and complex experimental designs.
• Microfluidics offers integrated solutions for sample handling and preparation within X-ray experimental setups.

Purpose of the Study:

• To review the integration of microfluidic devices with synchrotron X-ray measurements over the past 15 years.
• To highlight the advantages of microfluidics for mapping parameter spaces and studying kinetics.
• To discuss sample manipulation capabilities unique to microfluidic platforms at X-ray facilities.

Main Methods:

• In situ X-ray data collection directly on microfluidic platforms or sample jets.
• Review of microfluidic device designs and material considerations for X-ray compatibility.
• Analysis of applications in parameter space mapping, time-resolved kinetics, and advanced sample processing.

Main Results:

• Microfluidics enables efficient exploration of large parameter spaces in X-ray studies.
• Facilitates time-resolved investigations of mixing-induced reaction kinetics.
• Allows for sample manipulation and processing not feasible at the macroscale.

Conclusions:

• The combination of microfluidics and synchrotron X-ray measurements is a rapidly developing field.
• This integration offers significant potential for novel scientific discoveries and advanced experimental capabilities.
• Further advancements in microfluidic design and materials will expand its utility in X-ray science.