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Is it Time to Rethink the Use of Steroids for Pulmonary Leptospirosis?
Raajeev V Hingorani1, Rishi Kumar2, Ashit V Hegde3
1Resident Doctor.
The Journal of the Association of Physicians of India
|October 13, 2016
Summary
High-dose steroids for pulmonary leptospirosis (lung infection) can lead to severe fungal infections. Evidence supporting steroid use is limited, suggesting potential harm outweighs benefits.
Area of Science:
- Infectious Diseases
- Pulmonology
- Mycology
Background:
- Pulmonary involvement is a frequent complication of leptospirosis.
- High-dose corticosteroids are commonly prescribed for pulmonary leptospirosis.
Observation:
- Two cases developed severe invasive fungal infections after steroid treatment for pulmonary leptospirosis.
- These infections occurred despite the standard treatment protocol.
Findings:
- The routine use of steroids in pulmonary leptospirosis may increase the risk of secondary invasive fungal infections.
- The clinical evidence supporting the efficacy of high-dose steroids for this condition is sparse.
Implications:
- Clinicians should carefully weigh the risks and benefits of using high-dose steroids for pulmonary leptospirosis.
- Further research is needed to establish evidence-based treatment guidelines for pulmonary leptospirosis, potentially exploring steroid-sparing alternatives.
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