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Total Synthesis of Coprinol
Muthiah Suresh1, Navin Kumar1, Gorre Veeraraghavaiah2
1Centre for Applied Chemistry, Central University of Jharkhand , Brambe, Ranchi 835205, India.
Journal of Natural Products
|October 13, 2016
Abstract:
The first synthesis of coprinol has been achieved from 2-methoxy-3,5-dimethylbenzaldehyde via the intermediacy of an indanone derivative where dialkylation, Friedel-Crafts acylation, demethylation, and regioselective formation of a primary -OH group from a chloroacetyl group are the key steps.