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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

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Multiplex cell microarrays for high-throughput screening.

Ophélie I Berthuy¹, Sinan K Muldur², François Rossi²

¹Univ Lyon, Université Lyon1, CNRS, INSA, CPE-Lyon, ICBMS, UMR 5246, 43, Bd du 11 novembre 1918, 69622 Villeurbanne cedex, France. christophe.marquette@univ-lyon1.fr.

|October 13, 2016

Summary

This summary is machine-generated.

Cell microarrays enable high-throughput screening by miniaturizing assays for diverse applications like drug discovery. These optical cell microarray systems offer advanced high-content analysis capabilities.

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Area of Science:

Biotechnology
Cell Biology
Genomics

Background:

Microarray technology, developed in the 1990s, measures gene transcription levels.
Cell microarrays are an expansion of this technology for high-throughput cellular analysis.
Miniaturization in cell microarrays reduces reagent use and sample variability.

Purpose of the Study:

To provide an overview of recent advancements in optical cell microarrays.
To highlight their utility in high-throughput and high-content screening.
To discuss applications in drug discovery, toxicology, and stem cell research.

Main Methods:

Functionalization of substrate surfaces for cell microarray design.
Reverse transfection of plasmid DNA or siRNA onto cell microarrays.
Direct cell spotting using robotic fluid-dispensing or bio-ink printing.

Main Results:

Optical cell microarrays facilitate parallel, cell-based analysis.
These systems enable multiplex screening of cellular functions.
Advancements allow for direct cell deposition onto functionalized surfaces.

Conclusions:

Optical cell microarrays are powerful tools for high-throughput and high-content analysis.
Their miniaturized format offers efficiency and reduced sample heterogeneity.
Cell microarrays are versatile for various research and therapeutic applications.