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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Liver Histology01:27

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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Liver Physiology01:30

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Related Experiment Video

Updated: Mar 13, 2026

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

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Nonalcoholic Steatohepatitis.

Ayako Suzuki1, Anna Mae Diehl2

  • 1Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205.

Annual Review of Medicine
|October 13, 2016
PubMed
Summary
This summary is machine-generated.

Nonalcoholic steatohepatitis (NASH) is a growing cause of liver cirrhosis. This review explores why some individuals with fatty liver develop NASH and progress to cirrhosis.

Keywords:
adaptive mechanismshepatic fibrosishepatocyte damagelipotoxicitynonalcoholic fatty liver disease

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A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
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Area of Science:

  • Hepatology and Gastroenterology
  • Metabolic Disorders and Liver Disease

Background:

  • Nonalcoholic steatohepatitis (NASH) is a leading cause of liver cirrhosis and liver-related mortality globally.
  • NASH is closely linked to obesity and metabolic syndrome, characterized by lipid accumulation in liver cells (hepatic steatosis).
  • The specific factors driving NASH development and progression to cirrhosis remain incompletely understood.

Purpose of the Study:

  • To review the key mechanisms involved in NASH pathogenesis.
  • To discuss how variations in regulatory processes influence the risk of developing NASH and NASH-related cirrhosis.

Main Methods:

  • Literature review of current research on NASH pathogenesis.
  • Analysis of factors contributing to disease development and progression.
  • Synthesis of information on genetic and acquired regulatory variations.

Main Results:

  • Hepatic steatosis is a prerequisite for NASH, but not all individuals with steatosis develop NASH.
  • Specific molecular and cellular pathways are critical in NASH pathogenesis.
  • Individual variability in the regulation of these pathways significantly impacts disease risk.

Conclusions:

  • Understanding the determinants of NASH development and progression is crucial for effective management.
  • Inherent and acquired variations in key regulatory pathways are central to NASH and NASH cirrhosis risk.
  • Further research into these variations may reveal novel therapeutic targets.