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Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience
Lucas Sjulson1,2, Daniela Cassataro2, Shamik DasGupta3,4
1Department of Psychiatry, New York University School of Medicine, New York, NY 10016;
Annual Review of Genetics
|October 13, 2016
Summary
Genetically encoded tools allow precise targeting of specific neuron populations for in vivo visualization and manipulation, driving neuroscience advances. This review covers current methods and future improvements for cell-specific expression.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Genetically encoded tools are crucial for in vivo neuronal research.
- Targeting specific cell populations enhances experimental precision.
Purpose of the Study:
- To review current genetically encoded tools for neuronal targeting.
- To discuss practical implementation and future directions in cell-specific expression.
Main Methods:
- Review of existing literature on genetically encoded neuronal targeting tools.
- Analysis of methods based on marker gene expression, development, projection patterns, connectivity, and activity.
Main Results:
- Current methods allow targeting based on diverse cellular properties.
- Combinatorial targeting strategies offer increased specificity.
Conclusions:
- Genetically encoded tools have significantly advanced neuroscience by enabling precise cell targeting.
- Further improvements in practical implementation and targeting strategies are needed.
