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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Mar 13, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Advances in sarcoma diagnostics and treatment.

Amanda R Dancsok1, Karama Asleh-Aburaya1, Torsten O Nielsen1,2

  • 1Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Oncotarget
|October 13, 2016
PubMed
Summary

Sarcoma management is complex due to tumor diversity. Recent advances in molecular diagnostics and targeted therapies offer new hope, though clinical impact and immunotherapy are still developing.

Keywords:
sarcoma advancessarcoma diagnosticssarcoma reviewsarcoma therapeuticssoft tissue sarcoma

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Sarcomas are rare, heterogeneous neoplasms posing significant diagnostic and therapeutic challenges.
  • Management requires understanding molecular genesis, histology, and clinical presentation.
  • Recent research focuses on novel diagnostic and therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in sarcoma diagnostics and treatment.
  • To highlight the impact of molecular testing and emerging therapies.
  • To discuss the current state and future directions of sarcoma research.

Main Methods:

  • Review of recent international studies and clinical practice developments.
  • Analysis of transcriptome sequencing and next-generation sequencing applications.
  • Evaluation of cytotoxic, targeted, epigenetic, and immune therapy agents.

Main Results:

  • Molecular testing is increasingly integrated, influencing diagnosis and management, but outcome data is pending.
  • Transcriptome sequencing aids in identifying fusions and unclassified sarcomas.
  • Preclinical studies show promise for targeted agents in various signaling pathways; clinical progress is modest for conventional and targeted therapies.

Conclusions:

  • Molecular diagnostics are crucial for advancing sarcoma understanding and treatment.
  • Targeted and epigenetic therapies show preclinical potential, requiring further clinical validation.
  • Immunotherapy for sarcomas is nascent but progressing, with ongoing exploration of immune stimulation and checkpoint blockade.