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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: Mar 13, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

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Adult Stem Cell Therapy for Stroke: Challenges and Progress.

Oh Young Bang1,2, Eun Hee Kim2, Jae Min Cha3,4

  • 1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal of Stroke
|October 14, 2016
PubMed
Summary

Stem cell therapy for stroke shows modest efficacy and safety. Recent advances aim to overcome limitations in stem cell source, timing, potential, and adverse effects for improved stroke treatment.

Keywords:
BiomaterialsMesenchymal stem cellsStem cellsStroke

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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Neurology

Background:

  • Stroke remains a primary cause of adult mortality and disability.
  • Adult stem cell therapies for stroke, using mesenchymal stem cells and bone marrow mononuclear cells, have been explored for 15 years.
  • While safe, current adult stem cell therapies demonstrate modest efficacy, necessitating novel strategies.

Approach:

  • Discusses recent advancements in overcoming key limitations of adult stem cell therapy for stroke.
  • Addresses challenges including limited stem cell availability, critical treatment time windows, inherent stem cell limitations (growth, trophic support, differentiation), and risks of adverse effects like tumor formation.
  • Focuses on innovative approaches to enhance the therapeutic potential of stem cells in stroke recovery.

Key Points:

  • Identifies critical hurdles in current adult stem cell therapy for stroke.
  • Highlights the need for improved engraftable stem cell sources.
  • Explores strategies to optimize the therapeutic window and enhance stem cell function.
  • Discusses methods to mitigate risks associated with transplanted cells, such as tumorigenicity.

Conclusions:

  • Recent scientific progress offers potential solutions to limitations in adult stem cell therapy for stroke.
  • New strategies are emerging to improve the safety and efficacy of stem cell treatments for stroke patients.
  • Further research into these advances may lead to more effective regenerative therapies for stroke.