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Related Experiment Videos

Consensual pupillary light reflex in the pigmented rat.

L J Trejo1, M N Rand, C M Cicerone

  • 1Navy Personnel Research and Development Center, San Diego, CA 92152.

Vision Research
|January 1, 1989
PubMed
Summary

The pupillary light reflex (PLR) in rats shows a significant consensual response, contradicting previous claims of its absence. This study quanties the consensual PLR, finding it averages 78% of the direct PLR amplitude.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Animal Models

Background:

  • The pupillary light reflex (PLR) is a critical indicator of visual pathway function.
  • Previous research suggested a lack of consensual PLR in rodents, impacting understanding of visual processing.
  • Bilateral retinal projections to the pretectum in rats are known to subserve the PLR.

Purpose of the Study:

  • To quantitatively measure the direct and consensual pupillary light reflex (PLR) in Long Evans rats.
  • To challenge the notion that rodents lack a functional consensual PLR.
  • To compare the amplitude of the consensual PLR to the direct PLR in rats.

Main Methods:

  • Pupillary light reflex (PLR) was measured in 5 Long Evans rats under urethane sedation.
  • Three conditions were used: direct stimulation, consensual stimulation, and stray light control.

Related Experiment Videos

  • A ganzfeld stimulus (1.6 log quanta absorbed/rod/sec for 3 sec) was employed.

    • Main Results:

    • Direct PLR average constriction: 0.78 ± 0.07 mm.
    • Consensual PLR average constriction (corrected for stray light): 0.67 ± 0.06 mm.
    • The corrected consensual PLR reached 78% of the direct PLR amplitude.

    Conclusions:

    • Rodents exhibit a measurable consensual pupillary light reflex (PLR).
    • The findings contradict prior assertions of absent consensual PLR in rodents.
    • The observed consensual-to-direct PLR ratio is higher than predicted by anatomical studies of optic fiber projections.