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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

Marthe H R Ludtmann1, Plamena R Angelova1, Natalia N Ninkina2

  • 1Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 14, 2016
PubMed
Summary

Unfolded alpha-synuclein regulates mitochondrial energy production by interacting with ATP synthase. This finding reveals a new physiological role for alpha-synuclein, potentially impacting Parkinson's disease research.

Keywords:
ATP synthasealpha-synucleinastrocytesbioenergeticsmitochondrianeurons

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