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The Progress of Therapeutic Vaccination with Regard to Tuberculosis

Pere-Joan Cardona1

  • 1Unitat de Tuberculosi Experimental, Universitat Autònoma de Barcelona, CIBERES, Fundació Institut Germans Trias i Pujol Badalona, Spain.

Frontiers in Microbiology
|October 14, 2016
PubMed

Insights

Therapeutic vaccines show promise for shortening tuberculosis (TB) treatment. Research explores bacilli-directed and host-directed therapies to combat TB infection and disease progression.

Area of Science:

  • Immunology and Infectious Diseases
  • Vaccine Development
  • Microbial Pathogenesis

Background:

  • Prolonged drug therapy remains a significant challenge in controlling tuberculosis (TB), impacting both latent and active forms of the disease.
  • The need for improved TB treatment strategies necessitates exploration beyond conventional chemotherapy.

Approach:

  • Review of therapeutic vaccination strategies for tuberculosis, including bacilli-directed and host-directed approaches.
  • Analysis of vaccine candidates such as Mycobacterium w, RUTI, and the H56 fusion protein vaccine.
  • Examination of the role of inactivated Mycobacterium vaccae and heat-killed Mycobacterium manresensis in mitigating TB pathology.

Key Points:

  • Bacilli-directed therapies utilize inactivated whole or fragmented bacilli or fusion proteins with TB antigens.
  • Host-directed therapies aim to reduce tissue damage caused by the infection.
  • Specific mycobacterial preparations demonstrate potential in preventing adverse reactions and reducing inflammation in TB lesions.

Conclusions:

  • Therapeutic vaccination presents a promising avenue for enhancing tuberculosis control by potentially shortening treatment durations.
  • Further research into the evolution of Mycobacterium tuberculosis, TB immunology, and pathogenesis is crucial for developing definitive treatment and control strategies.
Keywords:
H56Mycobacterium indicus praniiMycobacterium manresensisMycobacterium tuberculosisMycobacterium vaccaeMycobacterium wneutrophilsvaccines

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