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Refractory necrotizing scleritis successfully treated with adalimumab

Lola E Lawuyi1, Avinash Gurbaxani2

  • 1, Gate 17, Villa 970 Al Raha Gardens, Abu Dhabi, United Arab Emirates. Lola27law@yahoo.co.uk.

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Keywords:
AdalimumabNecrotizing scleritisTNF inhibitors