Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients

Area of Science:

• Neuroscience
• Medical Technology
• Biomedical Engineering

Background:

• Multiple sclerosis (MS) is a chronic neurological disease affecting the brain.
• The therapeutic effects of ozone major autohemotherapy (OMH) on MS symptoms are known, but its impact on brain function remains unclear.
• Understanding cerebrovascular changes is crucial for assessing neurological recovery.

Purpose of the Study:

• To investigate the effects of OMH on the cerebrovascular patterns of MS patients and healthy subjects.
• To evaluate the functional and vascular changes in the brain during OMH using near-infrared spectroscopy (NIRS).
• To determine if OMH can improve brain metabolism and activity in MS patients.

Main Methods:

• Utilized near-infrared spectroscopy (NIRS) to monitor cerebrovascular patterns.
• Applied time, time-frequency, and nonlinear analysis to NIRS signals.
• Employed empirical mode decomposition to analyze intrinsic mode function signals.
• Compared changes in MS patients and normal subjects undergoing OMH.

Main Results:

• Observed an improvement in the cerebrovascular pattern across all subjects during OMH.
• NIRS signal entropy increased, indicating enhanced brain activity and vascular function.
• The findings suggest a positive impact of OMH on brain hemodynamics.

Conclusions:

• OMH positively influences cerebrovascular patterns in both MS patients and healthy individuals.
• The therapy appears to increase brain metabolism and restore activity levels.
• OMH shows potential as a supportive treatment for improving brain function in MS.