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Wilson's Disease with Systemic Lupus Erythematosus
Rpsp Santhakumar1, K Gayathri1, P K Ramalingam1
1Postgraduate.
The Journal of the Association of Physicians of India
|October 14, 2016
Summary
This case report details a rare instance of Wilson disease co-occurring with Systemic Lupus Erythematosus (SLE). Initial symptoms included fever and neuropsychiatric issues, highlighting diagnostic challenges.
Area of Science:
- * Neurology
- * Rheumatology
- * Hepatology
Background:
- * Wilson disease is a rare genetic disorder of copper metabolism.
- * Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease.
- * Co-occurrence of Wilson disease and SLE is exceptionally rare in medical literature.
Observation:
- * A patient presented with fever and neuropsychiatric symptoms.
- * Initial presentation mimicked other conditions, posing a diagnostic challenge.
- * Subsequent evaluation revealed coexisting SLE and Wilson disease.
Findings:
- * The case highlights the diagnostic complexity when rare diseases overlap.
- * Drug-induced lupus is a known complication of D-penicillamine treatment for Wilson disease, but this case involves coexisting idiopathic SLE.
- * Neuropsychiatric symptoms can be an early manifestation of both conditions.
Implications:
- * Clinicians should consider rare disease co-occurrences in complex presentations.
- * Early diagnosis and management are crucial for both Wilson disease and SLE.
- * This report contributes to the limited understanding of the interplay between these two distinct diseases.
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