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Hyaluronan/Tannic Acid Nanoparticles Via Catechol/Boronate Complexation as a Smart Antibacterial System
Elita Montanari1,2, Arianna Gennari1, Maria Pelliccia1
1NorthWest Centre of Advanced Drug Delivery (NoWCADD), Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.
Macromolecular Bioscience
|October 14, 2016
Summary
Hyaluronic acid nanoparticles deliver tannic acid effectively as an antimicrobial agent. These novel nanoparticles show enhanced antibacterial activity and potential for targeted drug delivery against bacterial infections.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Microbiology
Background:
- Hyaluronic acid (HA) is a natural polymer with potential for targeted drug delivery.
- Tannic acid (TA) possesses antimicrobial properties but can be unstable.
- Developing stable and effective antimicrobial formulations is crucial.
Purpose of the Study:
- To develop and characterize hyaluronic acid-based nanoparticles for tannic acid delivery.
- To evaluate the antimicrobial activity and toxicity of these novel nanoparticles.
- To assess the potential for targeted delivery to HA receptor-expressing cells.
Main Methods:
- Synthesis of HA-conjugated nanoparticles with 3-aminophenyl boronic acid (HA-APBA) and tannic acid (TA).
- Characterization of nanoparticle size and stability at different pH levels.
- Assessment of cytotoxicity on RAW 264.7 macrophages and antimicrobial efficacy against E. coli and S. aureus.
Main Results:
- Nanoparticle size varied with HA molecular weight (200-400 nm).
- Boronate ester linkages provided stability at physiological pH and release at acidic pH (5).
- HA-APBA/TA nanoparticles exhibited significantly enhanced antimicrobial activity compared to TA alone, with comparable efficacy to TA with ascorbic acid.
Conclusions:
- HA-APBA/TA nanoparticles offer a stable and effective system for tannic acid delivery.
- The nanoparticles demonstrate potential for targeted antimicrobial therapy, protecting TA from oxidation and enabling release in acidic environments.
- These findings support the development of advanced nanoparticle-based antimicrobial formulations.
