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Anti CCP Antibodies in Tuberculosis
Vikram Londhey1, Meghav M Shah2
1Associate Professor, Medicine Department, TNMC and BYL Nair Ch Hospital, Mumbai, Maharashtra.
The Journal of the Association of Physicians of India
|October 14, 2016
Summary
Anti-cyclic citrullinated peptide (anti-CCP) antibodies, often specific to rheumatoid arthritis, can be falsely positive in tuberculosis patients. This study found higher anti-CCP positivity in pulmonary tuberculosis than extra-pulmonary TB.
Area of Science:
- Immunology
- Infectious Diseases
- Rheumatology
Background:
- Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA).
- Previous research suggests potential cross-reactivity of anti-CCP antibodies in certain infectious diseases, including tuberculosis (TB).
Purpose of the Study:
- To investigate the prevalence and patterns of anti-CCP antibody positivity in patients diagnosed with tuberculosis.
- To assess the diagnostic specificity of anti-CCP antibodies in the context of TB infection.
Main Methods:
- A cohort of 50 patients with pulmonary and extra-pulmonary tuberculosis was recruited between May 2012 and November 2013.
- Anti-CCP antibody levels were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) technique for all participants.
Main Results:
- Anti-CCP antibodies were detected in 38.7% of pulmonary TB patients and 10.52% of extra-pulmonary TB patients.
- Within pulmonary TB, sputum-positive cases showed higher anti-CCP positivity (55.56%) compared to sputum-negative cases (31.81%).
- Overall, 12 out of 31 pulmonary TB patients and 2 out of 17 extra-pulmonary TB patients tested positive for anti-CCP antibodies.
Conclusions:
- Tuberculosis, particularly pulmonary TB, can lead to false-positive results for anti-CCP antibodies.
- The specificity of anti-CCP antibodies for rheumatoid arthritis may be compromised in patients with active tuberculosis.
- Further investigation is warranted to understand the immunological mechanisms underlying anti-CCP positivity in TB.
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