Related Experiment Video
Updated: Mar 13, 2026
Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
Anti CCP Antibodies in Tuberculosis
Vikram Londhey1, Meghav M Shah2
1Associate Professor, Medicine Department, TNMC and BYL Nair Ch Hospital, Mumbai, Maharashtra.
Introduction:
Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc.
Methods:
Fifty patients of tuberculosis both pulmonary and extra-pulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA.
Results:
Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extra-pulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies.
Conclusions:
Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis.
Related Concept Videos
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...