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Efficacy of simvastatin in reducing postoperative adhesions after thyroidectomy: an experimental study
Ozer Makay1, Dilek Isik1, Varlik Erol2
1a Department of General Surgery, School of Medicine , Ege University , Bornova , Izmir , Turkey.
Background:
We aimed to investigate whether simvastatin had any impact on the prevention of adhesion formation after thyroidectomy in a rat model.
Methods:
This study was performed in 66 Wistar albino rats randomized into three experimental groups. A right hemithyroidectomy was carried out in all the rats. Simvastatin was administered locally at a dose of 0.5 mg/kg and 0.8 mg/kg. Control rats received a saline solution only. Changes during the 1st week, 1st month and 3rd month were evaluated. Efficacy of the treatment was assessed by using a scoring system.
Results:
The severity of adhesions in low-dose simvastatin group was significantly less than the control and high-dose groups during the 1st and 3rd month (p < .05). In addition, adhesions were less in the high dose group during the 3rd month, when compared to the control group (p < .05). Moreover, fibrosis and fibroblast scores, which represent adhesions, were significantly lower in low-dose and high-dose groups at 3rd month, compared to controls (p < .05).
Conclusions:
We investigated the influence of simvastatin application on post-thyroidectomy adhesion formation in rats. Whether adhesions, causing technical difficulties during neck redo surgery, can be reduced by the use of simvastatin in human, needs to be studied.