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One Binder to Bind Them All.

Oliver Hayden1

  • 1Siemens Healthcare GmbH, Strategy and Innovation, Technology Center, In-Vitro DX & Bioscience, Günther-Scharowsky-Str. 1, 91058 Erlangen, Germany. oliver.hayden@siemens.com.

Sensors (Basel, Switzerland)
|October 14, 2016
PubMed
Summary
This summary is machine-generated.

Synthetic binders like molecularly imprinted polymers (MIPs) offer advantages over antibodies for chemical sensors. This work explores MIPs for biosensing, optimizing transducer-MIP integration for sensitive and reversible cell analysis.

Keywords:
aptamersbindercellsenvironmenthealthcarelife sciencelithographymolecularly imprinted polymersquartz crystal microbalancereceptorsensor

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • High-quality binders are crucial for chemical sensing, with antibodies being a traditional choice.
  • Synthetic alternatives like molecularly imprinted polymers (MIPs) offer faster development and enhanced binder stability.
  • The integration of MIPs with appropriate transducers is often overlooked but critical for effective sensing.

Purpose of the Study:

  • To discuss the industrial impact of synthetic binders in chemical sensing.
  • To challenge the molecular imprinting community to advance MIPs for biosensing applications.
  • To demonstrate application-driven development by integrating MIPs with piezoacoustic sensors.

Main Methods:

  • Review of industrial perspectives on synthetic binders for sensing.
  • Discussion on advancing molecularly imprinted polymers (MIPs) for biosensing.
  • Development and characterization of surface-imprinted MIP layers on piezoacoustic sensors.

Main Results:

  • Synthetic binders, particularly MIPs, present industrial advantages in sensor development time and stability.
  • Successful integration of surface-imprinted MIPs on piezoacoustic sensors for biosensing.
  • Demonstrated ability to tune sensor sensitivity from cell mass to cell viability by altering transducer electrode patterns.

Conclusions:

  • Molecularly imprinted polymers (MIPs) are a promising synthetic alternative to antibodies for chemical and biosensing.
  • Optimizing the transducer-MIP interface is key for application-specific sensor performance.
  • This work highlights a pathway for application-driven MIP biosensor development with tunable sensitivity and reversibility.