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Exploring human disease using the Rat Genome Database.

Mary Shimoyama1, Stanley J F Laulederkind2, Jeff De Pons2

  • 1Medical College of Wisconsin, Department of Surgery, Milwaukee, WI 53226, USA shimoyama@mcw.edu.

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|October 14, 2016
PubMed
Summary
This summary is machine-generated.

The Rat Genome Database (RGD) provides essential genomic and genetic data for laboratory rats, a key model for human disease research. RGD facilitates understanding complex diseases through curated data and comparative analysis with human and mouse genomes.

Keywords:
Data analysisDiseaseGenomicsOnline resourceRat Genome Database

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Area of Science:

  • Genomics and bioinformatics
  • Comparative genomics
  • Translational research

Background:

  • The laboratory rat (Rattus norvegicus) has been a vital model organism for over 150 years.
  • It is extensively used in toxicology, pharmacology, and complex disease studies.
  • The Rat Genome Database (RGD) has served as a premier resource for rat data since 1999.

Purpose of the Study:

  • To introduce the Rat Genome Database (RGD) and its comprehensive resources.
  • To highlight RGD's role in curating and validating rat genomic, genetic, and phenotype data.
  • To showcase RGD's tools and datasets for researchers studying human diseases using rat models.

Main Methods:

  • Curating and validating orthologous relationships between rat, human, and mouse genes.
  • Providing official nomenclature and unique identifiers for rat genetic elements.
  • Integrating functional, disease, pathway, and phenotype data for rat strains.

Main Results:

  • RGD offers a centralized repository of genomic, genetic, phenotype, and strain data for the laboratory rat.
  • The database validates orthologous gene relationships and provides standardized nomenclature.
  • RGD integrates diverse datasets and tools to support disease-related research and translational studies.

Conclusions:

  • RGD is an invaluable resource for researchers utilizing the laboratory rat for biomedical studies.
  • The database facilitates the understanding of human diseases by providing curated rat data and comparative genomics tools.
  • RGD supports translational research by enabling connections between rat-based insights and human health.