Evaluation of wound healing treated with latex derived from rubber trees and Aloe Vera extract in rats
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Updated: Mar 13, 2026
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020
Marcelo Luiz Brandão1, Paulo Roberto Melo Reis2, Lilhian Alves de Araújo3
1PhD, Associate Professor, Laboratory of Surgical Technique, School of Medical Sciences, Pharmaceutical and Biomedical, Pontificia Universidade Católica de Goiás (PUC-Goiás), Goiania-GO, Brazil. Intellectual, scientific and design of the study; acquisition and interpretation of data; technical procedures; critical revision; supervised all phases of the study.
Purpose::
To compare the use of latex derivative and Aloe vera extract to wound healing.
Methods::
Twenty one rats were randomly divided into three groups and each one had a wound made by incision. The treatment consisted in: derivative of latex (GL), Aloe vera extract (GA) and saline solution (GC). The wound area was measured on the 7th, 14th and 21st days and macroscopic and microscopic evaluation were done.
Results::
The comparison between the measurements of the wounds presented statistical difference in GC and GA from the 7th day of evaluation and GL from the 14th day. The extent of the wound was significantly smaller by the 7th day in GL. Histologically, in GL, the neovascularization was significant on the 7th, 14th and 21st days. On the 21st day the scar was large and little mature. In GA and GC, the findings were similar on the 7th, 14th and 21st days with a slight better organization of skin and collagen on the 21st in GA.
Conclusions::
Statistical analysis did not allow for the definition of the best topical agent. The latex had the highest angiogenesis, but a possible foreign body granuloma. Aloe vera has revealed a healing process adequated temporally in histology.
