Related Experiment Video
Updated: Mar 13, 2026
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
15.2K
Hypertriglyceridemia: Is there a role for prophylactic apheresis? A case report
Ana Rita Francisco1, Inês Gonçalves1, Fátima Veiga1
1Cardiology Department, Santa Maria University Hospital, Centro Hospitalar de Lisboa Norte, CCUL, University of Lisbon, Portugal.
Jornal Brasileiro De Nefrologia
|October 14, 2016
Summary
This case study highlights plasma exchange as a crucial intervention for severe hypertriglyceridemia, effectively lowering triglyceride levels and preventing complications like acute pancreatitis.
Area of Science:
- Cardiology
- Metabolic Disorders
- Hematology
Background:
- Severe hypertriglyceridemia is a significant risk factor for cardiovascular disease and acute pancreatitis.
- Metabolic syndrome and hypertrophic cardiomyopathy can contribute to extremely elevated triglyceride levels.
Observation:
- A 64-year-old woman presented with a triglyceride level of 3260 mg/dL, alongside hypertrophic cardiomyopathy and metabolic syndrome.
- The patient underwent plasma exchange combined with medical management to rapidly reduce triglyceride levels.
Findings:
- Three sessions of plasmapheresis resulted in a marked reduction in both triglyceride and total cholesterol levels.
- This intervention aimed to prevent potential clinical complications associated with severe hypertriglyceridemia.
Implications:
- Plasma exchange demonstrates applicability as a primary prophylactic measure in cases of extremely high serum triglyceridemia.
- This technique may be vital in managing patients at risk of pancreatitis and cardiovascular events due to severe hypertriglyceridemia.
Related Concept Videos
01:26Atherosclerosis III: Management
556
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
556
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.7K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
736
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
736
01:24Lipid Absorption
3.2K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.2K