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Effects of pericardiectomy on training- and myocardial infarction-induced left ventricular hypertrophy, chamber

A M Wolff1, T P Rasmussen1, C R Wichern1

  • 1Division of Kinesiology & Health.

International Journal of Sports Medicine
|October 14, 2016
PubMed

Insights

Pericardiectomy (PERI) did not alter exercise training or myocardial infarction (MI)-induced cardiac hypertrophy (LVH) or running performance in mice. However, PERI did impact left ventricular chamber dimensions in MI mice.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Surgical Intervention

Background:

  • Left ventricular hypertrophy (LVH) is an adaptive response to exercise training and a pathological consequence of myocardial infarction (MI).
  • The pericardium's role in modulating cardiac adaptation and performance is not fully understood.
  • Pericardiectomy (PERI) involves surgical removal of the pericardium.

Purpose of the Study:

  • To investigate the effects of pericardiectomy (PERI) on exercise training-induced and myocardial infarction (MI)-induced left ventricular hypertrophy (LVH).
  • To assess the impact of PERI on cardiac chamber geometry, gene expression, and running performance.
  • To determine if PERI modifies the cardiac response to physiological and pathological stimuli.

Main Methods:

  • Mice were randomized into six groups: control-sedentary, control-trained, PERI-sedentary, PERI-trained, MI-sedentary, and MI-trained.
  • Ten weeks of treadmill running assessed running performance to exhaustion.
  • 2D-echocardiography evaluated left ventricular (LV) dimensions, and gene expression of B-type natriuretic peptide (BNP) and β1-adrenergic receptor (β1-AR) were measured.

Main Results:

  • All trained groups exhibited enhanced running performance compared to sedentary groups (P<0.001).
  • Normalized LVH (LV/BW) increased similarly in control-trained and PERI-trained mice.
  • Stroke diameter was larger in PERI-treated mice compared to MI mice (P<0.01), but not control mice. BNP was elevated only in MI groups. β1-AR and melusin transcripts increased in trained mice.

Conclusions:

  • Long-term pericardiectomy did not enhance running performance or increase LVH in sedentary or trained mice.
  • PERI influenced LV chamber dimensions in the context of MI but did not exacerbate hypertrophy or impair performance.
  • The pericardium may play a role in modulating LV geometry post-MI, but its removal does not alter adaptive hypertrophy or exercise capacity.

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