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Updated: Mar 13, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Biology of anti-TNF agents in immune-mediated inflammatory diseases: therapeutic implications

Roger A Levy1, Renato Guzman2, Gilberto Castañeda-Hernández3

  • 1Discipline of Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Immunotherapy
|October 15, 2016
PubMed

Biologics are increasingly being used to modify the course of immune-mediated inflammatory diseases. Some main agents are monoclonal antibodies and a fusion-protein that target TNF. This group includes adalimumab, infliximab, certolizumab pegol, golimumab and etanercept. Although the efficacy of anti-TNFs is supported by numerous randomized clinical trials, their pharmacokinetics depend on many factors, in particular immunogenicity, which can cause marked and rapid clearance and a consequent decrease in efficacy. Kinetics involve receptors that recognize the Fc fragment of the antibody and are responsible for various processes. Pharmacological advances permit optimizing the pharmacokinetics of anti-TNFs. In this review, we examine the kinetics of anti-TNF biologics, and consequent therapeutic implications, and overview some latest developments in the field. First draftsubmitted: 17 May 2016; Accepted for publication: 15 September2016; Published online: 14 October 2016.

Keywords:
Fc receptor γ immunogenicityanti-TNFimmune-mediated inflammatory diseasesmonoclonal antibodiespharmacokinetics

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