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Aortic Valve Calcification and Risk of Stroke: The Rotterdam Study

Daniel Bos1, Atefeh Bozorgpourniazi2, Unal Mutlu2

  • 1From the Department of Radiology and Nuclear Medicine (D.B., A.B., M.W.V., A.M., M.A.I., A.v.d.L.), Department of Epidemiology (D.B., U.M., M.K., M.W.V., O.H.F., M.A.I.), and Department of Neurology (P.J.K., M.A.I.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (D.B.). d.bos@erasmusmc.nl.

Stroke
|October 15, 2016
PubMed

Insights

Aortic valve calcification (AVC) is common but does not increase stroke risk. This study found no association between AVC and prevalent or incident stroke in a large community-based cohort.

Area of Science:

  • Cardiology
  • Neurology
  • Epidemiology

Background:

  • Aortic valve calcification (AVC) is a frequent finding in older adults.
  • The relationship between AVC and stroke risk remains unclear.

Purpose of the Study:

  • To investigate whether aortic valve calcification is a risk factor for stroke.
  • To assess the association of AVC with prevalent and incident stroke.

Main Methods:

  • Utilized data from the population-based Rotterdam Study with 2471 participants.
  • Computed tomography quantified AVC; stroke was assessed at baseline and monitored for incidence.
  • Logistic and Cox regression models analyzed the associations.

Main Results:

  • AVC was present in 33.1% of participants.
  • No significant association was found between AVC and prevalent stroke (OR: 0.97; 95% CI: 0.61-1.53).
  • AVC did not increase the risk of incident stroke (HR: 0.99; 95% CI: 0.69-1.44).

Conclusions:

  • Despite being common, aortic valve calcification is not associated with an increased risk of stroke.
  • Findings suggest AVC may not be a significant predictor of stroke in the general community-dwelling population.
Abstract

Keywords:
aortic valvecalcificationcomputed tomographyfollow-up studiesstroke

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