Related Experiment Video

Updated: Mar 13, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

3.3K

Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD)

Rachel E Fargason1, Karen Gamble1, Kristin T Avis1

  • 1Dr. Fargason, MD, is Director of the Adult ADHD Clinic and an Associate Professor of Psychiatry & Behavioral Neurobiology. Dr. Gamble, PhD, is an Assistant Professor in the Department of Psychiatry & Behavioral Neurobiology. Dr. Avis, PhD, is an Associate Professor in Pediatrics. Ms. Besing, is a Graduate Research Assistant in the Behavioral Neuroscience program in the Psychology Department all at the University of Alabama at Birmingham School of Medicine. Dr. Cherry W. Jackson, PharmD, Professor of Pharmacy, Auburn University, Clinical Professor, Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham. Dr. Cates, PharmD, is a Professor of Pharmacy Practice at Samford University, McWhorter School of Pharmacy. Ms. May, MA, is an Assistant Professor in the Department of Psychiatry & Behavioral Neurobiology and Director of the Office of Psychiatric Clinical Research.

Psychopharmacology Bulletin
|October 15, 2016
PubMed
Summary

Ramelteon effectively advanced sleep timing in adults with ADHD and circadian rhythm sleep disorder (CRSD). However, it paradoxically increased sleep fragmentation and daytime sleepiness, requiring careful dosing considerations.

Keywords:
actigraphyattention disorderschildhood behavioral disorderchronobiologic treatmentscircadian rhythm disordercircadian rhythm sleep disorderdelayed sleep phasemelatonin agonistssleep-wake schedule disorder

More Related Videos

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.9K
Touchscreen Sustained Attention Task SAT for Rats09:31

Touchscreen Sustained Attention Task SAT for Rats

Published on: September 15, 2017

10.4K

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
758
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
770
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.2K
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.3K
Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
695
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K