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Updated: Mar 13, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Valproic Acid and Hepatic Steatosis: A Possible Link? About a Case Report
Leila Mnif1, Rim Sellami1, Jawaher Masmoudi1
1Dr. Leila Mnif, Professor, Department of Psychiatry «D», Razi University Hospital - Tunis-Tunisia. Drs. Rim Sellami, Assistant Professor and Jawaher Masmoudi, Professor, Department of Psychiatry «A», Hédi Chaker University Hospital - Sfax-Tunisia.
Background:
Valproic acid is a mood-stabilizing anticonvulsant. Hepatic injuries are among the occasionally observed adverse effects of this medication.
Case Presentation:
We present the case of a 47-year-old man who had bipolar disorder for ten years and treated with valproic acid. He demonstrated elevated serum aminotransferases and ultrasonography revealed that hepatomegaly was suggestive of hepatic steatosis.
Conclusion:
This case report stresses the importance of a complete drug history and the need for clinicians to be aware of the delayed onset of hepatic injuries.
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